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Cat. No. Product Name CAS No. Information
PC-35416

Baloxavir Marboxil

1985606-14-1 Baloxavir Marboxil (S-033188, Xofluza) is the prodrug of Baloxavir acid (S-033447) that potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses.

Influenza

Approved

PC-43395

Zanamivir

139110-80-8 Zanamivir is a hihly potent, broad-spetrum influenza viral neuraminidase (NA) inhibitor with IC50 of 0.95 nM and 2.7 nM for influenza A and B, respectively; inhibits plaque formation by laboratory-passaged strains of influenza A and B viruses,IC50 ranging from 0.005 to 0.014 uM; interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions.

Influenza

Approved

PC-42998

Pimodivir

1629869-44-8 Pimodivir (VX-787, JNJ872, JNJ 63623872) is a first-in-class, orally bioavailable inhibitor of influenza virus polymerase PB2 subunit with Kd of <3 nM, CPE EC50 of 2 nM; shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains with mean CPE EC50 of <2 nM; Pimodivir (VX-787) is highly efficacious in both prophylaxis and treatment models of mouse influenza and is superior to the neuraminidase inhibitor Oseltamivir.

Influenza

Phase 3 Clinical

PC-62612

Laninamivir

203120-46-1 Laninamivir (CS-8958) is a prodrug of the influenza neuraminidase (NA) inhibitor R-125489, shows long-acting anti-influenza virus activity.

Influenza

Approved

PC-62055

Favipiravir

259793-96-9 Favipiravir (T705) is a pyrazinecarboxamide derivative that is active against influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses; shows potent inhibitory activity against influenza A, B, and C viruses, with IC50s of 0.013 to 0.48 ug/ml.

Influenza

Approved

PC-45139

Peramivir

330600-85-6 An inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B.

Influenza

Approved

PC-45138

Peramivir trihydrate

1041434-82-5 An inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B.

Influenza

Approved

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