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Cat. No. Product Name CAS No. Information
PC-42564

Losmapimod

585543-15-3

Losmapimod (GSK-AHAB, GW856553X, SB856553) is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively; displays no significant activity for p38γ, p38δ (<25% inhibition at 10 uM), and COX-2; significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation in rat model of cardiovascular disease.

Ischemia

Phase 3 Clinical

PC-42692

Palosuran

540769-28-6 A potent and specific antagonist of human Urotensin (UT) receptor; inhibits 125I-U-II binding to human UT receptors in membrane preparations from CHO cells carrying the human UT receptors with IC50 of 3.6 nM; prevents the development of acute renal failure and the histological consequences of ischemia in rats.

Ischemia

Discontinued

PC-45567

Cilobradine

186097-54-1 A hyperpolarization-activated cyclic nucleotide-gated (HCN) channel; an open channel blocker of neuronal Ih and related cardiac If channels; strongly reduces the pacemaker diastolic depolarization rate and the cell's firing frequency.

Ischemia

Phase 1 Clinical

PC-45924

Cinepazide

23887-46-9 A cerebral vasodilator that acts as a calcium blocker; protect neuronal cells against OGD injury by suppressing OGD-induced oxidative stress and preserving mitochondrial functions.

Ischemia

Approved

PC-45923

Cinepazide maleate

26328-04-1 A cerebral vasodilator that acts as a calcium blocker; protect neuronal cells against OGD injury by suppressing OGD-induced oxidative stress and preserving mitochondrial functions.

Ischemia

Approved

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