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Cat. No. Product Name CAS No. Information
PC-61713

Tezampanel

150131-78-5

Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor; has neuroprotective and anticonvulsant properties, also has anxiolytic effects in animal studies.

Migraine

Discontinued

PC-35612

AMG-333

1416799-28-4 AMG-333 (AMG333, AMG 333) is a novel potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively; displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1); exhibits statistically significant and dose-dependent prevention of icilin-induced rat WDS, at 0.6, 1 and 3 mg/kg, inhibits cold-induced increase in blood pressure in the rat CPT in a dose-dependent manner with 1 and 3 mg/kg producing significant inhibition with an ED90 of 1.1 mg/kg, also fully blocks the cold pressor response at 3 mg/kg.

Migraine

Phase 1 Clinical

PC-35253

Ubrogepant

1374248-77-7 Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine.

Migraine

Phase 3 Clinical

PC-62994

MK-8825

1380887-60-4 MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.

Migraine

Phase 1 Clinical

PC-61868

Eletriptan

143322-58-1 Eletriptan (UK 116044) is a potent, selective, and orally active 5-HT1B/1D receptor agonist; significantly increases occluded wedge pressure and mean pulmonary artery pressure in vivo, with no significant coronary artery constriction, and obstructive coronary artery disease; displays antimigraine activity.

Migraine

Approved

PC-61867

Eletriptan hydrobromide

177834-92-3 Eletriptan (UK 116044) is a potent, selective, and orally active 5-HT1B/1D receptor agonist; significantly increases occluded wedge pressure and mean pulmonary artery pressure in vivo, with no significant coronary artery constriction, and obstructive coronary artery disease; displays antimigraine activity.

Migraine

Approved

PC-61714

Dasolampanel

503294-13-1 Dasolampanel (NGX426) is an orally bioavailable, competitive antagonist of the AMPA-kainate receptors for the treatment of chronic pain conditions including neuropathic pain and migraine.

Migraine

Discontinued

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