| Cat. No. |
Product Name |
Information |
| PC-61061 |
tBPC
Y4R PAM
|
tBPC is a potent, selective neuropeptide Y (NPY) receptor Y4R positive allosteric modulator (EC50=5.1 uM) that potentiates Y4R activation in G-protein signaling and arrestin3 recruitment experiments. |
| PC-28418 |
JNJ-31020028
Y2R antagonist
|
JNJ-31020028 is a potent, selective, brain penetran antagonist of neuropeptide Y Y2 receptor (Y2R) with binding pIC50 of 8.07 and 8.22 for human and rat Y(2) receptors, >100-fold selective versus human Y(1), Y(4), and Y(5) receptors. |
| PC-28044 |
NPSR1 antagonist Compound 6
NPSR1 antagonist
|
NPSR1 antagonist Compound 6 is a potent, selective and peripherally biased neuropeptide S receptor 1 (NPSR1, GPR154) with IC50 of 0.35 nM and 0.15 nM in calcium assay against NPSR1-A and NPSR1-B, respectively. |
| PC-27939 |
BIBP3226 TFA
Y1 receptor antagonist
|
BIBP3226 TFA (BIBP 3226) is a highly potent and selective non-peptide neuropeptide Y Y1 receptor (NPY1R) antagonist with Ki of 7 nM. |
| PC-27937 |
CGP71683A
Y5 receptor antagonist
|
CGP71683A (CGP71683 hydrochloride) is a potent, selective, competitive neuropeptide Y5 receptor (NPY5R) antagonist with Ki of 1.3 nM, shows little to no activity at Y1 receptor and Y2 receptor in cell membranes. |
| PC-26143 |
Y2R antagonist SF-11
Y2R antagonist
|
Y2R antagonist SF-11 is potent, selective and brain penetrant antagonist of Neuropeptide Y Y2 Receptor (Y2R) with IC50 of 199 nM, induces antidepressant-like effect in rats. |
| PC-23613 |
Hederagenin
NPFFR1 antagonist
|
Hederagenin is a triterpenoid saponin with antitumor activity against multifarious cancers, is a selective antagonist of neuropeptide FF receptor 1 (NPFFR1), selectively inhibits activation of NPFFR1 by NPFF or NPVF through orthosteric antagonism. |
