| Cat. No. |
Product Name |
Information |
| PC-21740 |
CVN766
OX1R inhibitor
|
CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R. |
| PC-20559 |
(R)-YNT-3708
OX1R agonist
|
(R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM). |
| PC-49188 |
OBPt-9
OXR1/2 potentiator
|
OBPt-9 is a potent, postivie allosteric potentiator of orexin receptor-mediated signaling, similarly potentiates the response of OXR1 and OXR2 to orexin A. |
| PC-38360 |
Firazorexton
OX2R agonist
|
Firazorexton (TAK-994) is a potent, selective, orally available and brain-penetrant agonist of orexin 2 receptor (OX2R) with EC50 of 19 nM against recombinant human OX2R, 700-fold selectivity against OX1R. |
| PC-73244 |
YNT-185
OX2R agonist
|
YNT-185 is a potent, selective orexin type-2 receptor (OX2R) agonist with EC50 of 28 nM, 100-fold selectivity over OX1R. |
| PC-72749 |
TAK-925
OX2R agonist
|
TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM). |
| PC-60727 |
ACT-541468
Orexin receptor antagonist
|
ACT-541468 (Nemorexant) is a potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively. |
| PC-60062 |
Suvorexant
Orexin receptor antagonist
|
Suvorexant (MK-4305, MK4305) is a potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively. |
| PC-42731 |
SB-334867 free base
OX1R inhibitor
|
SB-334867 is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4, displays 50-fold selectivity over OX2R (pKb 5.7). |
| PC-42730 |
SB-334867
OX1R inhibitor
|
SB-334867 (SB 334867A) is the first selective Orexin-1 receptor (OX1R) antagonist with pKb of 7.4. |
| PC-45747 |
MK-1064
OX2R inhibitor
|
MK-1064 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki/IC50 of 0.5/18 nM. |
| PC-42733 |
TCS 1102
Orexin receptor inhibitor
|
TCS 1102 is a potent and selective dual Orexin receptor antagonist with Ki of 0.2/3 nM for hOX2R/hOX1R respectively. |
