Under the agreement, the pair will work on a phase 1b trial to look into a number of new combos of Array's MEK inhibitor binimetinib and Pfizer's PARP inhibitor talazoparib alongside it and partner German Merck's PD-L1 Bavencio (avelumab), according to a statement. Pfizer will sponsor and bankroll the trial and Array will supply the binimetinib (MEK-162).
While the partners are starting non-small cell lung cancer and pancreatic cancer, they will investigate using the combos in other types of cancer later on.
"Preclinical data indicate that combining binimetinib with an immune checkpoint inhibitor and talazoparib could be a rational combination to test in the clinic," said Chris Boshoff, M.D., senior vice president and head of immuno-oncology, early development and translational oncology at Pfizer Global Product Development.
"We are looking forward to initiating the clinical studies with Array BioPharma to explore anti-tumor activity across various novel combination strategies, including both doublet and triplet approaches."
Talazoparib's original developer, BioMarin, sold it off in 2015 and the immuno-onology drug made its way to Pfizer in the Big Pharma's $14 billion acquisition of Medivation in August last year. And it's already showing promise—earlier this month, talazoparib improved progression-free survivalover chemo in a phase 3 trial involving patients with germline (inherited) BRCA1/2-positive (gBRCA+) locally advanced and/or metastatic breast cancer.