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Chemical Structure : (5Z)-7-Oxozeaenol
Catalog No.: PC-62868Not For Human Use, Lab Use Only.
(5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
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(5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively; inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38; also inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
| M.Wt | 362.37 | |
| Formula | C19H22O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Windheim M, et al. Biochem J. 2007 Jun 1;404(2):179-90.
2. Choo MK, et al. Mol Cancer Ther. 2006 Dec;5(12):2970-6.
3. Ninomiya-Tsuji J, et al. J Biol Chem. 2003 May 16;278(20):18485-90.
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