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Chemical Structure : (R)-HTS-3
Catalog No.: PC-38905Not For Human Use, Lab Use Only.
(R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids.
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(R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids.
(R)-HTS-3 inhibits LPCAT3 in a biphasic manner, possibly reflecting differential activity at each subunit of the LPCAT3 homodimer.
(R)-HTS-3 treatment cause rapid rewiring of polyunsaturated phospholipids in human cells.
LPCAT3 has been implicated in key biological processes such as intestinal lipid absorption, lipoprotein assembly, and ferroptosis.
| M.Wt | 300.377 | |
| Formula | C18H21FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alex Reed, et al. ACS Chem. Biol. 2022
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