| Cat. No. |
Product Name |
Information |
| PC-28510 |
Orniplabin
Plasminogen modulator, sEh inhibitor
|
Orniplabin (SMTP-7, Lemuplamor, Stachybotrys microspora triprenylphenol-7) is a fungal triprenyl phenol metabolite and plasminogen modulator, shows thrombolytic and anti-inflammatory effects, inhibits soluble epoxide hydrolase (sEH) to suppress inflammation, inhibits Cterm-EH and the Nterm-phos of sEH with IC50 of 23 uM and 6 uM. |
| PC-28496 |
DHPAAS inhibitor 1
Insect DHPAAS inhibitor
|
2,5,2',4'-tetrahydroxychalcone is a insect-specific inhibitor of DHPAAS 3,4-dihydroxyphenylacetaldehyde (DHPAA) synthase (DHPAAS), shows insecticide effect. |
| PC-28491 |
AKR-XI-85
RBP4 antatgonist
|
AKR-XI-85 is a potent, non-retinoid triazolopyrimidine Retinol-Binding Protein 4 (RBP4) antagonist with binding IC50 of 23 nM in SPA assay and 194 nM in TTR-RBP4 HTRF assay. |
| PC-28460 |
KPB82
ACER2 inhibitor
|
KPB82 is a potent and selective, competitive Alkaline ceramidase 2 (ACER2) inhibitor with IC50 of 190 nM, displaying minimal activity against ACER1, ACER3, ASAH1, or ASAH2. |
| PC-28457 |
ALCAT1-IN-1
ALCAT1 inhibitor
|
ALCAT1-IN-1 (Compound 222) is a potent and highly specific acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) inhibitor with IC50 of <15 nM. |
| PC-28453 |
NFAT inhibitor 14
NFAT inhibitor
|
NFAT inhibitor 14 is a small-molecule calcineurin-nuclear factor of activated T cells (NFAT) signaling inhibitor, inhibits the nuclear translocation and transcriptional activity of both NFATc1 and NFATc2, suppresses NFAT-dependent cytokine production, and shows cellular immunosuppressive activities. |
| PC-28436 |
A10P3C
EGLN2 inhibitor
|
A10P3C is a potent, isoform-selective inhibitor of prolyl hydroxylase EGLN2, effectively suppresses breast cancer cell proliferation, migration and invasion, induces G1 cell cycle arrest and cellular senescence through on-target EGLN2 inhibition. |
| PC-26013A |
GPR83 agonist CPD27
GPR83 agonist
|
GPR83 agonist CPD27 is a potent, selective small molecule GPR83 agonist with binding IC50 of 0.1 nM, and EC50 of 0.8 nM for [35S]GTPγS binding to membranes from CHO cells expressing mouse GPR83. |
| PC-28421 |
CMM-98
OGG1 activator
|
CMM-98 is a specific small molecule modulator / activator of DNA glycosylase OGG1 with AC50 of 38 nM and 83 nM on hOGG1 and mOGG1 respectively. |
| PC-28417 |
NGM1
NOS1AP modulator
|
NGM1 is a small molecule NOS1AP modulator of directly binds NOS1AP (CAPON) with SPR KD of 11.9 uM, alters NOS1AP-NOS1 (Nitric oxide synthase, nNOS) proximity, reduces viability in U87 and U251 GBM cells with IC50 values of 12.7 and 17.3 uM, respectively, with no effect on normal human astrocyte viability. |
| PC-28411 |
FOXC1-I4
FOXC1 inhibitor
|
FOXC1-I4 is a small-molecule inhibitor of Forkhead box C1 (FOXC1), binds FOXC1 (SPR KD=2.68 uM) and suppresses FOXC1 transcriptional activity. |
| PC-28384 |
DANA
Neuraminidase inhibitor
|
DANA (Neu5Ac2en, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid) is a potent Neuraminidas isoenyzmes (Sialidases, NEU) inhibitor with IC50 of 49, 43, 7.7, and 8.3 uM for NEU1, NEU2, NEU3, and NEU4, respectively, shows anti-influenza virus activity. |
