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Chemical Structure : (S)-BA-1049
Catalog No.: PC-20085Not For Human Use, Lab Use Only.
(S)-BA-1049 is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.
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(S)-BA-1049 is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.
Neither BA-1049 nor the metabolite inhibits PKA or PKC at physiological ATP concentrations.
BA-1049 is a promising drug candidate to reduce lesion growth and hemorrhage in both CCM1 and CCM3 models of cavernous angioma (CA).
| M.Wt | 319.42 | |
| Formula | C16H21N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lisa McKerracher, et al. Transl Stroke Res. 2020 Jun;11(3):365-376.
2. Patent US20170313680A1.
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