(S)-Retro-2.1 | Retrograde transport inhibitor

Chemical Structure : (S)-Retro-2.1

(S)-Retro-2.1 (Retro-2.1a)

Catalog No.: PC-27431Not For Human Use, Lab Use Only.

Retro-2.1a ((S)-Retro-2.1) is a potent molecule to counteract the cytotoxic potential of ricin and Shiga toxin with EC50 of 23 nM and 54 nM, respectively, blocking retrograde transport and intracellular retrograde trafficking.

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Biological Activity

Physicochemical Properties

M.Wt	435.54
Formula	C23H18FN3OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-fluoro-1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

References

1. Gupta N, et al. ACS Med Chem Lett. 2013 Dec 4;5(1):94-7.

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(S)-Retro-2.1 (Retro-2.1a)

Biological Activity

Physicochemical Properties

References

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