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(±)-Huperzine A

Chemical Structure : (±)-Huperzine A

CAS No.: 120786-18-7

(±)-Huperzine A (Huperzine A)

Catalog No.: PC-45211Not For Human Use, Lab Use Only.

A naturally occurring sesquiterpene alkaloid that a reversible and selective inhibitor of acetylcholinesterase (AChE).

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Biological Activity

A naturally occurring sesquiterpene alkaloid that a reversible and selective inhibitor of acetylcholinesterase (AChE); has been used for improving memory, cognitive and behavioral function in Alzheimer's disease; activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.

Alzheimer's Disease

Approved

Physicochemical Properties

M.Wt 242.3162
Formula C15H18N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (11E)-

References

1. Burshtein G, et al. Planta Med. 2013 Mar;79(3-4):259-65.

2. Wang J, et al. J Neurosci Res. 2010 Mar;88(4):807-15.

3. Wang CY, et al. Neuropsychopharmacology. 2011 Apr;36(5):1073-89.

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