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Cat. No. Product Name CAS No. Information
PC-63361

Zanapezil

263248-42-6 Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM; ameliorates the passive avoidance deficit induced by diazepam in animal models at 1-3 mg/kg, ameliorates the impairment of DMTP performance induced by scopolamine without affecting the general behavior of the rats.

Alzheimer Disease

Phase 3 Discontinued

PC-62461

Ipidacrine hydrochloride hydrate

118499-70-0 Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.

Alzheimer Disease

Phase 3 Discontinued

PC-62460

Ipidacrine hydrochloride

90043-86-0 Ipidacrine hydrochloride is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.
PC-61036

TAK-802 hydrochloride

263248-36-8 A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition; increases rhythmic bladder contractions in Guinea pigs and rats without affecting the basal intravesical pressure.

Other Indication

Phase 2 Discontinued

PC-61035

TAK-802

263248-16-4 A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition; increases rhythmic bladder contractions in Guinea pigs and rats without affecting the basal intravesical pressure.

Other Indication

Phase 2 Discontinued

PC-60067

AD-35 hydrochloride

1531586-62-5 A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
PC-60066

AD-35

1531586-58-9 A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

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