Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : 2-PCCA
Catalog No.: PC-61115Not For Human Use, Lab Use Only.
A potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM; inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway; dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine; does not alter the behavioral effects of methamphetamine in rats alone.
| M.Wt | 455.646 | |
| Formula | C30H37N3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7.
2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.
3. Jin C, et al. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
