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Chemical Structure : 20(S)-Hydroxycholesterol
Catalog No.: PC-62201Not For Human Use, Lab Use Only.
20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site.
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20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site; activates Hedgehog (Hh) signaling (EC50 =3 uM for induction of Hh reporter gene transcription in in NIH 3T3 cells); induces Smo accumulation in primary cilia.
| M.Wt | 402.65 | |
| Formula | C27H46O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nedelcu D, et al. Nat Chem Biol. 2013 Sep;9(9):557-64.
2. Nachtergaele S, et al. Nat Chem Biol. 2012 Jan 8;8(2):211-20.
3. Dwyer JR, et al. J Biol Chem. 2007 Mar 23;282(12):8959-68.
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