Cat. No. |
Product Name |
Information |
PC-36044 |
Glasdegib
Smoothened inhibitor
|
Glasdegib (PF-04449913) is a potent, orally bioavailable smoothened (SMO) inhibitor with IC50 of 5 nM in the Gli-luciferase reporter assays, binds to human SMO (AA181-787) with IC50 of 4 nM. |
PC-35986 |
MU1300
Hedgehog modulator
|
MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly. |
PC-62178 |
CUR61414
Hh signaling inhibitor
|
CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM). |
PC-62171 |
SANT-1
Smoothened inhibitor
|
SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling. |
PC-62169 |
Saridegib
|
Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM. |
PC-61149 |
Smoothib
|
Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM. |
PC-42586 |
Vismodegib
Smoothened inhibitor
|
Vismodegib (GDC-0449) is a potent, selective, orally bioavailable smoothened (Smo) inhibitor, blocks Shh signaling with EC50 of 40 nM. |
PC-20089 |
MRT-92
Smoothened inhibitor
|
MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM. |
PC-38710 |
Sonidegib phosphate
Smoothened inhibitor
|
Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. |
PC-38709 |
Sonidegib
Smoothened inhibitor
|
Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. |
PC-43422 |
LY2940680
|
LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas. |
PC-43256 |
SAG
|
SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM). |