25C-NBF | 5-HT2A agonist | Probechem Biochemicals

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Chemical Structure : 25C-NBF

25C-NBF (25C-NBF hydrochloride)

Catalog No.: PC-25761Not For Human Use, Lab Use Only.

25C-NBF is a potent, selective 5-HT2A agonist with binding Ki of 0.8 nM and calcium mobilization EC50 of 2.3 nM, displays 2625-, 180-, 59-fold selective over 5-HT1A, 5-HT2B and 5-HT2C receptors respectively, exhibits antidepressant effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	360.25
Formula	C17H20Cl2FNO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzeneethanamine, 4-chloro-N-[(2-fluorophenyl)methyl]-2,5-dimethoxy-, hydrochloride (1:1)

References

1. Nadal-Gratacós N, et al. Mol Psychiatry. 2025 Nov 14. doi: 10.1038/s41380-025-03341-1.

2. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9.

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25C-NBF (25C-NBF hydrochloride)

Biological Activity

Physicochemical Properties

References

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