| Cat. No. |
Product Name |
Information |
| PC-27530 |
IHCH-8110
5-HT2AR agonist
|
IHCH-8110 is a potent, selective non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist, inhibits CRC progression by activating 5-HT2AR on enteric glial cells, thereby inducing CXCL10 and IL-18 expression to promote CD8+ T cell recruitment and effector polarization within the tumor microenvironment. |
| PC-27525 |
Mosapride
5-HT4 agonist
|
Mosapride (AS-4370) is a gastroprokinetic agent that acts as a selective 5-HT4 agonist, has concentration-dependent inhibitory effect on Kv4.3. |
| PC-27155 |
DSP-2342
5-HT2A/5-HT7 antagonist
|
DSP-2342 is potent, selective 5-hydroxytryptamine 2A/7 (5-HT2A/5-HT7) receptor antagonist with binding Ki of 1.15 nM and 2.92 nM for human 5-HT2A and 5-HT7 respectively, IC50 of 24.8 nM and 4.4 nM. |
| PC-26559 |
JZ-1201
SERT/NET inhibitor, 5-HT1A agonist
|
JZ-1201 is a selective serotonin (5-HT)/norepinephrine (NE) reuptake inhibitor and partial agonist of the 5-HT1A receptor, selectively binds to the SERT, NET, and 5-HT1A receptor with Ki values of 1.62 nM, 0.87 nM, and 0.22 nM, exerts antidepressant-like effects. |
| PC-25986 |
DOI-NBOMe
5-HT2A agonist
|
DOI-NBOMe is a potent, selective and Gq-biased agonist of 5-HT2A receptor (5-HT2AR) with pEC50 of 8.01. |
| PC-25733 |
TMU4142
5-HT1A agonist
|
TMU4142 is a potent, GoA pathway-selective 5-HT1A receptor (5-HT1AR) agonist with pEC50 of 8.80 (EC50=1.59 nM), Emax=92.78%. |
| PC-25028 |
Remlifanserin
5-HT2A inverse agonist
|
Remlifanserin (ACP-204, ACP204) is a potent, selective 5-HT2A serotonin receptor inverse agonist with Ki of 0.14 nM, acts as an antagonist/inverse agonist and has potencies of 0.3-0.5 nM. |
| PC-24197 |
AAZ-A-154
5-HT2R ligand
|
Zalsupindole (AAZ-A-154) is a potent, highly selective non-hallucinogenic psychLight competitive ligand/antagonist of 5-HT2A receptor (5-HT2AR), exhibits antidepressant-like effects. |
| PC-24117 |
Bretisilocin
5-HT2A agonist
|
Bretisilocin (GM-2505) is a potent, selective 5-HT2A receptor agonist with the EC50 of 5.54 nM. |
| PC-22530 |
RE104
5-HT2A agonist
|
Luvesilocin (RE104) is the prodrug of 4-OH-DiPT, a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM. |
| PC-22277 |
SB269970
5-HT7 antagonist
|
SB269970 (SB-269970) is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors. |
| PC-21971 |
Bexicaserin
5-HT2C agonist
|
Bexicaserin (LP352) is a potent, highly selective, oral and centrally acting 5-HT2C receptor agonist with EC50 of 42 nM (Emax=112%), and Ki of 39 nM. |
