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40569Z

Chemical Structure : 40569Z

CAS No.: 2640673-56-7

40569Z

Catalog No.: PC-20271Not For Human Use, Lab Use Only.

40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

Physicochemical Properties

M.Wt 667.77
Formula C32H34FN5O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

diethyl (R)-5-(2-((5-((3-fluorobenzamido)methyl)-4-phenethyl-4H-1,2,4-triazol-3-yl)thio)propanamido)-3-methylthiophene-2,4-dicarboxylate

References

1. Chen Zhang, et al. Front Cell Dev Biol. 2022 Jan 31;9:813233.

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