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Cat. No. Product Name CAS No. Information
PC-35760

MDL-800

MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays; dramatically enhanced SIRT6 deacetylation activity by more than 22-fold, displays no activity toward SIRT1, SIRT3, SIRT4, and HDAC1-11 at 50-100 uM, as well as >10-fold selectivity toward SIRT2, SIRT5, and SIRT7; activates SIRT6 through a surface allosteric site induces H3K9ac and H3K56ac deacetylation and represses proliferation of HCC cells (IC50=23.3 uM); inhibits xenograft tumor growth of HCC cells in immunocompromised mice by activating the deacetylase activity of SIRT6.

PC-60123

SirReal2

1848251-24-0

SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.

PC-35584

E1231

1031195-19-3 E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models.
PC-35524

SRTCX1003

1203480-93-6 SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner, decreases the production of the proinflammatory cytokines TNFα and IL-12 in acute mouse model of LPS-induced inflammation.
PC-35523

SRTCX1002

1203479-63-3 SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
PC-43528

Tenovin-1

380315-80-0 Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2; causes significantly greater growth inhibition, cell death via apoptosis, as well as superior p53 promoter upregulation in wtp53 MyLa cells when combined with vorinostat; elicits caspase-mediated cell death in p53 wild-type cells, but caspase-independent cell death in p53 null cells.
PC-63273

OSS-128167

887686-02-4 OSS-128167 is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively; increases H3K9 acetylation and GLUT-1 expression in treated cells.

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