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Chemical Structure : 4E2RCat
CAS No.: 432499-63-3
Catalog No.: PC-42237Not For Human Use, Lab Use Only.
A small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $264 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay; inhibits cap-dependent translation in a dose-dependent manner, significantly decreases human coronavirus 229E (HCoV-229E) replication, reduces the percentage of infected cells and intra- and extracellular infectious virus titers.
| M.Wt | 455.9339 | |
| Formula | C22H14ClNO4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15.5 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]- |
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1. Cencic R, et al. J Virol. 2011 Jul;85(13):6381-9.
2. Cencic R, et al. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51.
3. Bhat M, et al. Nat Rev Drug Discov. 2015 Apr;14(4):261-78.
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