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Chemical Structure : 5-HT2A antagonist 11c
Catalog No.: PC-21787Not For Human Use, Lab Use Only.
5-HT2A antagonist 11c is a potent, selective, peripheral 5HT2A antagonist with IC50 of 14 nM.
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5-HT2A antagonist 11c is a potent, selective, peripheral 5HT2A antagonist with IC50 of 14 nM.
5-HT2A antagonist 11c shows good chemical, hepatocyte, and plasma stability, no significant cytotoxicity in five representative mammalian cell lines (VERO, HFL-1, L929, NIH3T3, CHO-K1).
5-HT2A antagonist 11c shows selective inhibition of 5HT2A among other 5-HT subtypes.
5-HT2A antagonist 11c (5 and 10 mpk) daily oral gavage attenuates HFD-induced obesity, MASLD, and metabolic syndrome.
5-HT2A antagonist 11c shows vivo efficacy against CDAHFD-induced liver fibrosis and inflammation C57BL/6 J mice.
5-HT2A antagonist 11c is a novel peripheral 5HT2A antagonist for Metabolic Dysfunction-Associated Steatohepatitis (MASH) and steatosis under clinical investigations.
| M.Wt | 517.07 | |
| Formula | C30H33ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Haushabhau S Pagire, et al. Nat Commun. 2024 Jan 20;15(1):645.
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