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Chemical Structure : 6RK73
Catalog No.: PC-73132Not For Human Use, Lab Use Only.
6RK73 is a potent, specific and covalent UCHL1 inhibitor with IC50 of 0.23 uM.
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6RK73 is a potent, specific and covalent UCHL1 inhibitor with IC50 of 0.23 uM.
6RK73 displays a high selectivity over other DUBs including its closest family members UCHL3 and UCHL5.
6RK73 shows more potent inhibition than LDN57444 on UCHL1 activity in MDA-MB-436 cells by TAMRA ABP assay.
6RK73 is comparable to genetic knockdown of UCHL1.
6RK73 displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells, which is stronger than the effect of shRNA-mediated UCHL1 knockdown.
6RK73 potently inhibits breast cancer migration and extravasation.
| M.Wt | 307.372 | |
| Formula | C13H17N5O2S | |
| Appearance | Solid | |
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1. Liu S, et al. Clin Cancer Res. 2020 Mar 15;26(6):1460-1473.
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