| Cat. No. |
Product Name |
Information |
| PC-28121 |
USP1 inhibitor 38a
USP1 inhibitor
|
USP1 inhibitor 38a is a potent, oral bioavailable deubiquitinating enzyme USP1 inhibitor, dose-dependently induces Ub-PCNA accumulation, triggers cell cycle arrest, and potently suppresses cell viability. |
| PC-27996 |
USP8 inhibitor W-17
USP8 inhibitor
|
USP8 inhibitor W-17 is a potent, selective USP8 inhibitor with IC50 of 108 nM, exhibits no activity against USP7, USP10, and USP14 (IC50>10 uM). |
| PC-27977 |
Ubistatin A
Ubiquitin-proteasome system inhibitor
|
Ubistatin A (ubiA, Ubistatin-A) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, can penetrate cancer cells and alters cellular ubiquitin landscape. |
| PC-27976 |
Ubistatin B
Ubiquitin-proteasome system inhibitor
|
Ubistatin B (ubiB, Ubistatin-B) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, can penetrate cancer cells and alters cellular ubiquitin landscape. |
| PC-27903 |
USP15-IN-1
USP15 inhibitor
|
USP15-IN-1 is a small molecule ubiquitin-specific peptidase 15 (USP15) inhibitor with IC50 of 3.76 uM, has USP15 inhibitory activity and anticancer activity. |
| PC-27899 |
USP20 inhibitor C2
USP20 inhibitor
|
USP20 inhibitor C2 is a small molecule Ubiquitin-Specific Protease 20 (USP20) inhibitor with IC50 of 13.55 uM (300 nM Ub-Rho110 as substrate), directly deubiquitinates and stabilizes fatty acid synthase (FASN), suppresses de novo lipogenesis (DNL) to alleviate MASLD. |
| PC-27640 |
CT1170
OTUD5 inhibitor
|
CT1170 is a potent, small molecule inhibitor of deubiquitinase OTUD5 with IC50 of 147.6 nM in DUB assays, enhances the ubiquitination modification on STAT1 and STAT2. |
| PC-26962 |
DC-U43-10
USP8 inhibitor
|
DC-U43-10 (USP8-IN-1) is a specific small molecule USP8 inhibitor with IC50 of 2.6 uM, exhibits 10-fold selectivity against USP7. |
| PC-26913 |
TH-407a
USP15 inhibitor
|
TH-407a is a potent and selective, reversible, non-competitive inhibitor of ubiquitin-specific peptidase 15 (USP15) with IC50 of 0.76 uM. |
| PC-26655 |
Berberine
USP22 inhibitor, HIF1α degrader
|
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation |
| PC-26593 |
Huib32
USP32 inhibitor
|
Huib32 is a potent, selective small-molecule inhibitor of USP32 with IC50 of 21.2 nM, high selectivity over other closely related deubiquitinating enzymes (DUBs). |
| PC-26500 |
WEHI-092
USP9X inhibitor
|
WEHI-092 is a potent and selective inhibitor of USP9X with IC50 of 254 nM, directly binds to USP9X catalytic domain with SPR KD of 1 uM, does not inhibit USP24 and other DUBs. |
