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7-BIA

Chemical Structure : 7-BIA

CAS No.: 1313403-49-4

7-BIA (PTPRD inhibitor 7-BIA)

Catalog No.: PC-35733Not For Human Use, Lab Use Only.

7-BIA is a small molecule 7-butoxy illudalic acid analog that targets receptor-type protein tyrosine phosphatase D (PTPRD, IC50=1-3 uM) with some specificity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

7-BIA is a small molecule 7-butoxy illudalic acid analog that targets receptor-type protein tyrosine phosphatase D (PTPRD, IC50=1-3 uM) with some specificity.
7-BIA weakly inhibits PTPRS (IC50=40 uM), displays IC50>100 uM at any of many tested receptors, transporters, or sites of action of other drugs.
7-BIA reduces cocaine-conditioned place preference in mice without toxicity, 7-BIA provides a lead compound for addiction therapeutics.

Physicochemical Properties

M.Wt 294.303
Formula C15H18O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-butoxy-3-hydroxy-6-methoxy-1-oxoisochromane-5-carbaldehyde

References

1. Uhl GR, et al. Proc Natl Acad Sci U S A. 2018 Oct 22. pii: 201720446.

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