| Cat. No. |
Product Name |
Information |
| PC-21457 |
K161
SHIP1/2 inhibitor
|
K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
| PC-20712 |
SBI-668
SHP2-E76K inhibitor
|
SBI-668 is a selective inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM in isothermal CETSA assays, 7-fold selectivity over SHP2-WT (IC50=15 uM). |
| PC-20711 |
SBI-221
SHP2-E76K inhibitor
|
SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively. |
| PC-20365 |
HN252
PPM1B inhibitor
|
HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro. |
| PC-20341 |
PHPS1 sodium
SHP2 inhibitor
|
PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20340 |
PHPS1
SHP2 inhibitor
|
PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20250 |
JAB-3068
SHP2 inhibitor
|
JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 with IC50 of 25.8 nM. |
| PC-20047 |
GDC-1971
SHP2 inhibitor
|
Migoprotafib (GDC-1971, RLY-1971) is a potent, selective, allosteric and orally bioavailable inhibitor of the non-receptor protein tyrosine phosphatase SHP2 (PTPN11), potently inhibits both wild-type SHP2 (IC50 <1 nM) and E76K activating mutant (IC50 < 250nM) in biochemical assays. |
| PC-49364 |
SPAA-52
LMW-PTP inhibitor
|
SPAA-52 is a highly potent, selective inhibitor of the low-molecular-weight protein tyrosine phosphatase (LMW-PTP) with Ki of 1.2 nM, >8000-fold selectivity over other PTPs. |
| PC-49299 |
DS-1211
TNAP inhibitor
|
DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM. |
| PC-49084 |
NSC49L
PP2A agonist
|
NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. |
| PC-49039 |
PP2Cδ (WIP1) inhibitor C23
PP2Cδ inhibitor
|
PP2Cδ inhibitor C23 is a potent PP2Cδ (WIP1, PPM1D) inhibitor, not only directly inhibits PP2Cδ activity but also suppresses high glucose (HG)-induced PP2Cδ expression. |
