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A-443654

Chemical Structure : A-443654

CAS No.: 552325-16-3

A-443654 (A 443654;A443654)

Catalog No.: PC-42579Not For Human Use, Lab Use Only.

A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases.
A-443654 inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM.
A-443654 inhibits tumor growth in vivo, and is more potent and more selective than A-674563.

Physicochemical Properties

M.Wt 397.4723
Formula C24H23N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Indole-3-ethanamine, .alpha.-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (.alpha.S)-

References

1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.

2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.

3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.

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