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Chemical Structure : A-484954
CAS No.: 142557-61-7
Catalog No.: PC-70180Not For Human Use, Lab Use Only.
A-484954 (A484954) is a highly selective, small molecule eEF2K inhibitor with IC50 of 0.28 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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A-484954 (A484954) is a highly selective, small molecule eukaryotic elongation factor 2 kinase (eEF2K) inhibitor with IC50 of 0.28 uM.
A-484954 inhibits eEF2K and reduces eEF2 phosphorylation with little effect on cancer cell growth.
A-484954 inhibits MCT-induced PA hypertrophy and fibrosis in rats, inhibits MCT-induced NOX1 expression, ROS generation and MMP-2 activation.
| M.Wt | 289.29 | |
| Formula | C13H15N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide |
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1. Chen Z, et al. J Biol Chem. 2011 Dec 23;286(51):43951-8.
2. Edupuganti R, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4910-6.
3. Kameshima S, et al. Am J Physiol Heart Circ Physiol. 2015 May 15;308(10):H1298-305.
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