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Chemical Structure : A-674563
CAS No.: 552325-73-2
Catalog No.: PC-43433Not For Human Use, Lab Use Only.
A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
A-674563 increases the efficacy of paclitaxel in a PC-3 xenograft model.
A-674563 enhances the transcription of several chondrocyte marker genes, including Col2a1, Acan and Col11a2, in mouse primary chondrocytes by inhibiting Sox9 degradation through the ubiquitin-proteasome pathway.
A-674563 also suppresses FLT3-ITD positive AML both in vitro and in vivo.
| M.Wt | 358.44 | |
| Formula | C22H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzeneethanamine, a-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (aS)- |
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1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.
3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.
4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.
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