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Chemical Structure : A-770041
Catalog No.: PC-42786Not For Human Use, Lab Use Only.
A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM.
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A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM.
A-770041 shows 60-fold selective against Src, 95-fold selective against Fgr and 300-fold selective against Fyn.
A-770041 inhibits anti-CD3 induced IL-2 with EC50 of 80 nM; orally bioavailable.
| M.Wt | 621.7319 | |
| Formula | C34H39N9O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stachlewitz RF, et al. J Pharmacol Exp Ther. 2005 Oct;315(1):36-41.
2. Burchat A, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22.
3. Duan Z, et al. BMC Cancer. 2014 Sep 19;14:681.
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