Chemical Structure : A-796260
CAS No.:
895155-26-7
A-796260
Catalog No.: PC-26033Not For Human Use, Lab Use Only.
A-796260 is a potent, selective cannabinoid CB2 receptor agonist with binding Ki of 4.37 nM and 13.0 nM for human and rat CB2 receptors respectively, >30-fold selective over CB1 receptor.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A-796260 is a potent, selective cannabinoid CB2 receptor agonist with binding Ki of 4.37 nM and 13.0 nM for human and rat CB2 receptors respectively, >30-fold selective over CB1 receptor.
a potent and efficacious agonist at human and rat CB2 receptors with EC50 values of 0.710 nM (Emax of 78%) and 1.63 nM (Emax of 69%), respectively.
A-796260 is highly selective at CB2 receptors, exhibiting 1380- and 175-fold selectivity at human and rat CB2 receptors compared to CB1 receptors of the respective species.
A-796260 dose-dependently attenuated CFA-induced thermal hyperalgesia (ED50=2.8 mg kg−1 i.p.,).
A-796260 dose-dependently attenuated dose-dependently attenuated tactile allodynia on skin incision-induced acute postoperative pain.
Physicochemical Properties
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M.Wt
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354.49
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Formula
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C22H30N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)-methanone
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References
1. Yao BB, et al. Br J Pharmacol. 2008 Jan;153(2):390-401.
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