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Chemical Structure : A-803467
CAS No.: 944261-79-4
Catalog No.: PC-42804Not For Human Use, Lab Use Only.
A-803467 (A803467) potent and selective Nav1.8 sodium channel blocker with IC50 of 8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $248 | In stock | |
| 250 mg | Get quote |
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A-803467 (A803467) is a potent and selective Nav1.8 sodium channel blocker with IC50 of 8 nM.
A-803467 displays >100-fold selectivity versus human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50s>1 uM).
A-803467 potently blocks tetrodotoxin-resistant currents (IC50= 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons.
A-803467 attenuates neuropathic and inflammatory pain in the rat.
| M.Wt | 357.7876 | |
| Formula | C19H16ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Furancarboxamide, 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)- |
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1. Jarvis MF, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5.
2. McGaraughty S, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):1204-11.
3. Joshi SK, et al. J Pain. 2009 Mar;10(3):306-15.
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