Cat. No. |
Product Name |
Information |
PC-49224 |
AM-0466
NaV1.7 inhibitor
|
AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM). |
PC-47036 |
QX-314 chloride
Sodium channel blocker
|
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels, also inhibits calcium currents in hippocampal CA1 pyramidal neurons. |
PC-38662 |
ABBV-318
Nav1.7/ Nav1.8 blocker
|
ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively. |
PC-73070 |
XPC-6444
NaV1.6 inhibitor
|
XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM). |
PC-72898 |
BI 1265162
ENaC inhibitor
|
BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively. |
PC-72850 |
NBI-921352
NaV1.6 inhibitor
|
NBI-921352 (XEN901, NBI 921352) is a potent, highly selective, orally active inhibitor of NaV1.6 with IC50 of 51 nM (hNaV1.6 channel currents inhibition). |
PC-72674 |
PRAX-562
Persistent INa inhibitor
|
PRAX-562 (PRAX562) is a novel persistent sodium current (INa) inhibitor, inhibits hNaV1.6 persistent INa induced by ATX-II or SCN8A mutation N1768D with IC50 of 141 and 75 nM, respectively. |
PC-72192 |
GDC-0276
NaV1.7 inhibitor
|
GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM. |
PC-72191 |
GDC-0310
NaV1.7 inhibitor
|
GDC-0310 (GDC 0310 ) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.8 nM (hNaV1.7), cellular sodium influx IC50 of 16 nM. |
PC-72189 |
DS-1971a
NaV1.7 inhibitor
|
DS-1971a (DS1971a) is a highly potent, selective NaV1.7 inhibitor with IC50 of 22.8 nM (hNaV1.7) and 59.4 nM (mNaV1.7). |
PC-38297 |
BI-8668
ENaC inhibitor
|
BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay). |
PC-35155 |
PF-05661014
|
PF-05661014 is a potent, selective Nav1.3 inhibitor with IC50 of 0.26 uM, shows no activity for Nav1.7 (IC50>10 uM). |