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Chemical Structure : A-922500
CAS No.: 959122-11-3
Catalog No.: PC-42121Not For Human Use, Lab Use Only.
A-922500 (A922500) is a potent, selective and orally bioavailable DGAT-1 inhibitor with IC50 of 9 and 22 nM against human and mouse DGAT-1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | $728 | In stock | |
| 1 g | Get quote |
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A-922500 (A922500) is a potent, selective and orally bioavailable DGAT-1 inhibitor with IC50 of 9 and 22 nM against human and mouse DGAT-1, respectively.
A-922500 demonstrates excellent selectivity over other acyltransferases, including DGAT-2 (IC50=53 uM) and ACAT-1/2 (IC50=296 uM).
A-922500 significantly reduces serum triglyceride (TG) levels in both genetic and diet-induced animal models of hypertriglyceridemia.
| M.Wt | 428.4798 | |
| Formula | C26H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclopentanecarboxylic acid, 2-[[4'-[[(phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]-, (1R,2R)- |
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1. Zhao G, et al. J Med Chem. 2008 Feb 14;51(3):380-3.
2. King AJ, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):526-31.
3. King AJ, et al. Eur J Pharmacol. 2010 Jul 10;637(1-3):155-61.
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