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Chemical Structure : A4276
Catalog No.: PC-21428Not For Human Use, Lab Use Only.
A4276 is a novel orally bioavailable NAMPT inhibitor with IC50 of 492 nM for inhibiting NAMPT enzymatic activity, shows high selectivity for NAPRT-deficient lung cancer cell lines.
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A4276 is a novel orally bioavailable NAMPT inhibitor with IC50 of 492 nM for inhibiting NAMPT enzymatic activity, shows high selectivity for NAPRT-deficient lung cancer cell lines.
A4276 exhibits remarkable selectivity against NAPRT-deficient EMT-like cancer cell lines across various cancer types while effectively sparing NAPRT-positive cells, particularly, normal cells.
A4276 (100 mg/kg) potently inhibits the growth of NAPRT-negative EMT-subtype cancer in in HGC27 xenografts. A4276 delays Wallerian degeneration, prevents chemotherapy-induced peripheral neuropathy (CIPN).
| M.Wt | 343.39 | |
| Formula | C21H17N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Minjee Kim, et al. Theranostics. 2023 Sep 11;13(14):5075-5098.
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