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Chemical Structure : A779
CAS No.: 159432-28-7
Catalog No.: PC-21224Not For Human Use, Lab Use Only.
A779 is a potent, selective antagonist of angiotensin-(1-7) receptor Mas, blocks the antidiuretic effect of Ang-(1-7) in vivo.
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|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $588 | In stock | |
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A779 is a potent, selective antagonist of angiotensin-(1-7) receptor Mas, blocks the antidiuretic effect of Ang-(1-7) in vivo.
A779 inhibited antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral medulla.
A-779 did not change the dipsogenic, pressor, or myotropic effects of angiotensin II (Ang II).
A-779 did not affect the antidiuretic effect of vasopressin or the contractile effects of angiotensin III, bradykinin, or substance P on the rat ileum.
| M.Wt | 872.97 | |
| Formula | C39H60N12O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-L-Isoleucine-7-D-alanine-1-7-angiotensin II |
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1. Santos RA, et al. Brain Res Bull. 1994;35(4):293-8.
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