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Cat. No. Product Name CAS No. Information
PC-43383

EMA401

1316755-16-4 EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM; EMA401 is a novel peripherally-restricted analgesic, may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways.

Pain

Phase 2 Clinical

PC-43020

CGP-42112

127060-75-7 CGP-42112 (CGP42112A) is a highly potent, selective Angiotensin-II subtype 2 receptor(AT2 receptor) agonist with Ki of 0.24 nM; significantly inhibits cGMP production from the basal value, also significantly inhibits TH-enzyme activity from the basal value in cultured porcine adrenal medullary cells; antagonizes Ang-II induced contractions in rabbit aortic rings with IC50 of 1.85 uM.
PC-43019

Angiotensin 1-7

51833-78-4 Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM; augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide, abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2; evokes anti-arrhythmogenic effects in animal models, upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats.
PC-62642

EMA300

136676-76-1 EMA300 (PD1 21981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over AT1 receptor, produces analgesia in rodent model of neuropathic pain.
PC-70201

Candesartan

139481-59-7 An angiotensin II receptor antagonist used mainly for the treatment of hypertension.

Hypertension

Approved

PC-45692

BIBS-39

133085-33-3 BIBS-39 is a selective nonpeptide angiotensin II receptor antagonist with Ki of 29 nM and 480 nM for AT1 and AT2 respectively; shows no high affinity for other receptors, shifts the AII concentration-contractile response curves in isolated rabbit aorta with pA2 of 8.14 and a slope of 1.06; shows effective antihypertensives in the model of the renal hypertensive rat.
PC-45274

Azilsartan medoxomil monopotassium

863031-24-7 An orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.

Hypertension

Approved

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