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AA92593

Chemical Structure : AA92593

CAS No.: 457961-34-1

AA92593 (AA 92593)

Catalog No.: PC-38201Not For Human Use, Lab Use Only.

AA92593 is a selective and competitive OPN4 (melanopsin) antagonist with IC50 of 665 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AA92593 is a selective and competitive OPN4 (melanopsin) antagonist with IC50 of 665 nM.
AA92593 attenuated melanopsin photocurrent in a dose-dependent manner, inhibited melanopsin photoresponses without inhibiting rod/cone function.
AA92593 reversibly attenuated melanopsin-mediated photoresponses.

Physicochemical Properties

M.Wt 269.359
Formula C13H19NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((4-methoxy-3-methylphenyl)sulfonyl)piperidine

References

1. Kenneth A Jones, et al. Nat Chem Biol. 2013 Oct;9(10):630-5.

2. Qiushi Wang, et al. Mol Cancer Res. 2020 Jul;18(7):1028-1038.

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