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Chemical Structure : AAT-008
Catalog No.: PC-61499Not For Human Use, Lab Use Only.
A novel potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM.
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A novel potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM; shows little or no activity for hEP1/2/3 (IC50>1890 nM); inhibits PGE2-induced cAMP in human EP4 transfectant with pA2 of 8.97; exhibits significantly improved pharmacological profiles over grapiprant in acute and chronic inflammatory pain models in rats.
| M.Wt | 414.817 | |
| Formula | C21H16ClFN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Okumura Y, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1186-1192.
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