Chemical Structure : ABBV-552
CAS No.:
1651179-19-9
ABBV-552
(SDI-118, ABBV552)
Catalog No.: PC-27727Not For Human Use, Lab Use Only.
ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A).
ABBV-552 (SDI-118) has high selectivity over other SV2 isoforms, SV2B (over 1000-fold) and SV2C (over 100-fold).
ABBV-552 (SDI-118) enhances synaptic efficiency by increasing presynaptic neurotransmitter release.
ABBV-552 (SDI-118) shows promising cognitive function improvement in some neurological disorders.
Physicochemical Properties
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M.Wt
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330.70
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Formula
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C13H10ClF3N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-((5-chloro-1H-1,2,4-triazol-1-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
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References
1. Botermans W, et al. Front Pharmacol. 2023 Jan 17;13:1066447.
2. Miles N, et al. Eur J Clin Pharmacol. 2026 Jul 21;82(8):214.
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