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ABT-072

Chemical Structure : ABT-072

CAS No.: 1132936-00-5

ABT-072 (ABT072)

Catalog No.: PC-62637Not For Human Use, Lab Use Only.

ABT-072 is a novel, orally bioavailable non-nucleoside HCV NS5B polymerase inhibitor with EC50 of 0.3 nM (GT1b).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ABT-072 is a novel, orally bioavailable non-nucleoside HCV NS5B polymerase inhibitor with EC50 of 0.3 nM (GT1b); a new direct-acting antivirals (DAAs) for the treatment of HCV infection.

HCV Infection

Phase 2 Discontinued

Physicochemical Properties

M.Wt 469.556
Formula C24H27N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N-(4-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide

References

1. Randolph JT, et al. J Med Chem. 2018 Feb 8;61(3):1153-1163.

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