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Cat. No. Product Name CAS No. Information
PC-61440

Voxilaprevir

1535212-07-7

Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.

HCV Infection

Phase 2 Clinical

PC-35585

Cyclophilin inhibitor C31

Cyclophilin inhibitor C31 (SMCypI C31) is a small-molecule cyclophilin (CypA) inhibitor (SMCypI) with PPIase inhibition IC50 of 0.1 uM, displays anti-HCV activity (HCV Gt1b replicon EC50=0.4 uM) and disrupts the CypA-NS5A interaction; exerts at least additive antiviral effects when combined with the NS5A inhibitor ledipasvir and is fully active against ledipasvir-resistant viruses; also inhibits the replication of other members of the Flaviviridae family (DENV EC50=7.3 uM), YFV EC50, 27.2 uM, and ZIKV EC50=48.0 uM), without significant cytotoxicity.
PC-35444

Coblopasvir

1312608-46-0 Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection.

HCV Infection

Phase 3 Clinical

PC-35056

Ciluprevir

300832-84-2 Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively; inhibits the replication of HCV replicon 1b and 1a with IC50 of 3 nM and 4 nM, respectively.

HCV Infection

Phase 2 Discontinued

PC-35032

BI-1388

1309952-03-1 BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K; BI-1388 was shown to be highly selective against other serine/cysteine proteases, binds to the active site of NS3 that is located in the shallow and broad protein-protein interaction surface of the protease- and the helicase domain of the enzyme.
PC-63573

MK-3281

886041-60-7 MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.

HCV Infection

Phase 1 Discontinued

PC-63572

Beclabuvir hydrochloride

958002-36-3 Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively; inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of <30 nM; the combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1 in clinical trials.

HCV Infection

Phase 1 Discontinued

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