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Chemical Structure : ABT-288
Catalog No.: PC-63032Not For Human Use, Lab Use Only.
ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively.
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ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively; enhances the release of acetylcholine and dopamine in rat prefrontal cortex; possesses excellent pharmacokinetics and oral bioavailability.
| M.Wt | 372.472 | |
| Formula | C23H24N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Esbenshade TA, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45.
2. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97.
3. Othman AA, et al. Br J Clin Pharmacol. 2014 Jun;77(6):965-74.
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