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Chemical Structure : ABT-702
Catalog No.: PC-38790Not For Human Use, Lab Use Only.
ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.
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ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.
ABT-702 displays several orders of magnitude selectivity over other sites of ADO interaction (A(1), A(2A), A(3) receptors, ADO transporter, and ADO deaminase), and 1300- to 7700-fold selective for ADK compared with a number of other neurotransmitter and peptide receptors, ion channel proteins, neurotransmitter/nucleoside reuptake sites, and enzymes, including COX-1 and -2.
ABT-702 is orally active and fully efficacious in reducing acute somatic nociception (ED50 = 8 micromol/kg i.p.; 65 micromol/kg p.o.) in the mouse hot-plate assay.
ABT-702 also dose dependently reduced nociception in the phenyl-p-quinone-induced abdominal constriction assay.
ABT-702 dispalyed analgesic and anti-inflammatory properties in vivo.
| M.Wt | 463.339 | |
| Formula | C22H19BrN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kowaluk EA, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.
2. Lee CH, et al. J Med Chem. 2001 Jun 21;44(13):2133-8.
3. Suzuki R, et al. Br J Pharmacol. 2001 Apr;132(7):1615-23. al.
4. Jarvis MF, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.
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