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ABT-751

Chemical Structure : ABT-751

CAS No.: 141430-65-1

ABT-751 (ABT751;ABT 751;E7010;E-7010;E 7010)

Catalog No.: PC-43449Not For Human Use, Lab Use Only.

ABT-751 (E-7010) is an orally active antimitotic agent that inhibits tubulin polymerization, exhibits consistent growth-inhibitory activities against a panel of human tumor cell lines (IC50=0.06-0.8 ug/mL).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ABT-751 (E-7010) is an orally active antimitotic agent that inhibits tubulin polymerization, exhibits consistent growth-inhibitory activities against a panel of human tumor cell lines (IC50=0.06-0.8 ug/mL); shows good antitumor activity against various rodent tumors and human tumor xenografts,

Lung Cancer

Discontinued

Physicochemical Properties

M.Wt
Formula C18H17N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 48 mg/mL

Chemical Name/SMILES

Benzenesulfonamide, N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-

References

1. Koyanagi N, et al. Cancer Res. 1994 Apr 1;54(7):1702-6.

2. Yoshimatsu K, et al. Cancer Res. 1997 Aug 1;57(15):3208-13.

3. Segreti JA, et al. Cancer Chemother Pharmacol. 2004 Sep;54(3):273-81.

4. Yoshimatsu K, et al. Cancer Res. 1997 Aug 1;57(15):3208-13.

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