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Cat. No. Product Name CAS No. Information
PC-42620

Lexibulin dihydrochloride

917111-49-0

An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo; inhibits a broad selection of cancer cell lines with IC50 of <100 nM; blocks the cell cycle at the G2-M boundary and increases phosphorylated Bcl-2, expression of cyclin B1; orally bioavailable, and efficacious in a range of in vivo cancer models.

Blood Cancer

Phase 2 Discontinued

PC-42619

Lexibulin

917111-44-5

An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo; inhibits a broad selection of cancer cell lines with IC50 of <100 nM; blocks the cell cycle at the G2-M boundary and increases phosphorylated Bcl-2, expression of cyclin B1; orally bioavailable, and efficacious in a range of in vivo cancer models.

Blood Cancer

Phase 2 Discontinued

PC-45982

Cephalomannine

71610-00-9

A taxol derivative with antitumor, antiproliferative properties.

Chemotherapeutic Agents

Approved

PC-42466

Ixabepilone

219989-84-1

A semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer; shows a broad spectrum of activity against a panel of tumor cell lines in vitro (IC50=1.4-34.5 nM), retains the antineoplastic activity against human cancers that are resistance to paclitaxel both in vitro and in vivo.

Breast Cancer

Approved

PC-45256

4|-Demethylepipodophyllotoxin

6559-91-7

A potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds.

PC-45268

Fosbretabulin disodium

168555-66-6

A derivative of combretastatin that acts as a microtubule destabilising agent; damage the vasculature (blood vessels) of cancer tumours causing central necrosis.

Chemotherapeutic Agents

Phase 3 Clinical

PC-45239

Vinblastine

865-21-4

A cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules; a chemotherapy agent for treatment of a number of types of cancer.

Chemotherapeutic Agents

Approved

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