Chemical Structure : ABT-E79
CAS No.:
1372143-02-6
ABT-E79
Catalog No.: PC-27617Not For Human Use, Lab Use Only.
ABT-E79 is a highly potent and selective PGK1 inhibitor, significantly inhibits TNBC cell proliferation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ABT-E79 is a highly potent and selective PGK1 inhibitor, significantly inhibits TNBC cell proliferation.
ABT-E79 significantly inhibited TNBC cell proliferation, as evidenced by cell viability and colony formation assays.
ABT-E79 also markedly reduced MDSC migration in 4T1 cells.
ABT-E79 induced a dose-dependent decrease in intracellular lactate levels and decreased Pan Kla and H3K18la in TNBC cells.
ABT-E79 significantly reduced CCL5 expression at both the transcript and protein levels in MDA-MB-231 cells, with a similar reduction observed in 4T1 cells.
ABT-E79 significantly inhibited tumor growth and progression in orthotopic TNBC xenograft models.
ABT-E79 induced marked reduction in total MDSCs, including both the M-MDSC and PMN-MDSC subsets.
ABT-E79 enhanced PD-1 blockade efficacy in TNBC, restores antitumor immunity.
Physicochemical Properties
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M.Wt
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304.78
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Formula
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C15H17ClN4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(7-chloro-2,3-bis(ethylamino)quinoxalin-6-yl)prop-2-yn-1-ol
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References
1. Wang YP, et al. Acta Pharmacol Sin. 2026 Aug 4. doi: 10.1038/s41401-026-01875-w.
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