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Chemical Structure : AC3573
Catalog No.: PC-72379Not For Human Use, Lab Use Only.
AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM.
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AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM.
AC3573 abrogates HER2–HER3 signalling in cells and is more specific for HER3, inhibits NRG (heregulin)-induced HER3 phosphorylation with IC50 of 10 uM, abrogates the formation of the active HER2-HER3 heterodimer, inhibits oncogenic downstream signalling in SK-BR-3 breast cancer cells.
| M.Wt | 365.411 | |
| Formula | C18H15N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Audrey Colomba, et al. Biochem J. 2020 Sep 18;477(17):3329-3347.
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