| Cat. No. |
Product Name |
Information |
| PC-21761 |
BI-4732
EGFR inhibitor
|
BI-4732 is a potent, highly BBB penetrant, fourth-generation EGFR inhibitor against EGFR activating mutations, including C797S. |
| PC-20669 |
Zongertinib
|
Zongertinib is a potent tyrosine kinase inhibitor with antineoplastic activity. |
| PC-49365 |
EGFR inhibitor 57
EGFR L858R inhibitor
|
EGFR inhibitor 57 is a novel potent, selective, allosteric fourth-generation EGFR L858R inhibitor, overcomes EGFRC797S-mediated resistance in NSCLC harboring the activating EGFRL858R mutation. |
| PC-49235 |
DSF-102
EGFR ECD inhibitor
|
DSF-102 (DSF102) is a small molecule EGFR inhibitor that interacts with the extracellular domain (ECD) of EGFR, inhibits the interaction with the EGF instead of blocking the intracellular kinase activity, shows inhibition of EGFR dimerization with IC50 of 13.2 uM. |
| PC-49227 |
BI-1622
HER2 inhibitor
|
BI-1622 (BI 1622) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 7 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR. |
| PC-49226 |
BI-4142
HER2 inhibitor
|
BI-4142 (BI 4142) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 5 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR. |
| PC-47006 |
OBX02-011
EGFR TKI
|
OBX02-011 is a potent, reversible, fourth-generation EGFR tyrosine kinase inhibitor (TKI) that overcomes the EGFR C797S mutation, inhibits triple mutants Del19/T790M/C797S and L858R/T790M/C797S with IC50 of 0.134 and 2.09 nM, respectively. |
| PC-38578 |
JBJ-08-178-01
HER2 inhibitor
|
JBJ-08-178-01 is a potent, selective and covalent HER2 inhibitor with IC50 of 2.21 nM and 7.04 nM for HER2 WT and EGFR WT, targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification (IC50 values<50 nM). |
| PC-38347 |
ASK120067
EGFR mutant inhibitor
|
ASK120067 (Limertinib) is a novel third-generation inhibitor of EGFR T790M (L858R/T790M IC50=0.3 nM, T790M IC50=0.5 nM), with selectivity over EGFR WT (IC50=6 nM). |
| PC-38346 |
TAS-121
EGFR mutant inhibitor
|
TAS-121 (TAS 121) is an orally available, potent, novel third-generation EGFR-TKI that selectively targets EGFR activating and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38345 |
Oritinib mesylate
mutant EGFR inhibitor
|
Oritinib mesylate (SH-1028) is an irreversible third-generation EGFR inhibitor, selectively and specifically inhibits EGFR active mutations and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38344 |
Oritinib
mutant EGFR inhibitor
|
Oritinib (SH-1028) is an irreversible third-generation EGFR inhibitor, selectively and specifically inhibits EGFR active mutations and T790M resistance mutations, sparing wild-type EGFR. |
