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Chemical Structure : AD-5584
Catalog No.: PC-21663Not For Human Use, Lab Use Only.
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
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AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-5584 specifically binds ACSS2 (KD=188 uM) but not the mitochondrial isoform hACSS1.
AD-5584 leads to a significant reduction in lipid storage, reduction in colony formation, and increase in cell death in MDA-MB-231BR cells.
AD-5584 significantly reduces tumor size and synergizes with radiation in blocking BCBM tumor growth in an ex vivo orthotopic brain-slice tumor model.
| M.Wt | 414.91 | |
| Formula | C22H24ClFN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emily Esquea, et al. bioRxiv. December 23, 2023
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